RT Journal
A1 Schwartz CE
T1 A surfeit of serotonin: Sumatriptan and serotonergic antidepressants
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD May 24
VO 159
IS 10
SP 1141
OP 1141
DO 
UL http://dx.doi.org/
AB 
The article by Knudsen et al1 presents their astute clinical observation of a series of 8 cases of ischemic colitis in patients being treated with sumatriptan succinate. This is a heretofore unreported association and represents a potentially critical side effect involving extracranial vasoconstriction. In speculating about the cause, the authors discuss the possibility of drug-drug interactions, noting that 7 of the 8 patients in their series were taking other concurrent medication(s) in addition to the sumatriptan.