RT Journal
A1 Daniell HW
T1 GAstroesophageal reflux disease stimulation of nsaid-associated atrial fibrillation
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD April 11
VO 171
IS 7
SP 702
OP 710
DO 10.1001/archinternmed.2011.107
UL http://dx.doi.org/10.1001/archinternmed.2011.107
AB 
The association between atrial fibrillation (AF) and nonsteroidal anti-inflammatory drug (NSAID) use demonstrated by De Caterina et al1 may be augmented by at least 2 common mechanisms not included among those that they proposed. Reflux esophagitis is extremely common during NSAID use and has been independently associated with AF2; its treatment with protein pump inhibitors (PPIs) has been associated with less frequent AF.3- 4 Prolonged, habitual, physical effort, which may increase NSAID use, may also induce a much greater frequency of AF,5 potentially contributing to the NSAID-AF association.