RT Journal
A1 Goldstein MR, Mascitelli L, Pezzetta F
T1 PLatelet inhibition and cancer promotion
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD November 22
VO 170
IS 21
SP 1943
OP 1944
DO 10.1001/archinternmed.2010.420
UL http://dx.doi.org/10.1001/archinternmed.2010.420
AB 
It has been shown in rodents that the platelet inhibitor, clopidogrel, increases the regulatory T-cell (Treg) pool and also increases splenic-derived endothelial progenitor cells.3 An increase in Tregs might impair host antitumor immune responses; indeed, Treg numbers in many solid tumors have correlated inversely with patient survival.4 In addition, it has become evident that endothelial progenitor cells promote tumor angiogenesis and are found more frequently in the peripheral blood and tumors of patients with more invasive disease.5