RT Journal
A1 Rosch PJ
T1 COuld proton pump inhibitors cause cancer?
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD October 25
VO 170
IS 19
SP 1775
OP 1776
DO 10.1001/archinternmed.2010.375
UL http://dx.doi.org/10.1001/archinternmed.2010.375
AB 
In addition to increased risk of osteoporotic fractures, Clostridium difficile, and other infections,1 proton pump inhibitors (PPIs) may have also contributed to the sharp rise in gastroesophageal malignant diseases seen over the past 2 decades. This is especially true for esophageal adenocarcinoma, which was previously uncommon, and mirrors the increased use of these drugs.2- 3 It has been suggested that with PPIs, pancreatic enzymes that would have previously been inactivated by hydrochloric acid are able to irritate and cause dysplasia in esophageal tissue in patients with reflux disease. There is also evidence that gastroesophageal reflux disease (GERD) may not develop from direct superficial injury but rather from stimulation of esophageal cytokines that attract inflammatory cells to submucosal tissues.4