RT Journal
A1 Wang C, Ma M, Fang C, Chen S, Yen Z
T1 HIgh or low doses of ppis for patients with peptic ulcer bleeding?—reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD October 11
VO 170
IS 18
SP 1699
OP 1700
DO 10.1001/archinternmed.2010.354
UL http://dx.doi.org/10.1001/archinternmed.2010.354
AB 
We thank all the correspondents for their comments. Calvet et al and Lin raised concerns about the inclusion of the trials containing low-risk patients. In our subgroup analysis,1 there were 792 high-risk patients, with 401 and 391 patients in high-dose and non–high-dose groups, respectively. Although the confidence intervals were wide, no significant difference was noted in rebleeding, surgical intervention, or mortality. We still regarded it as a hint that high-dose IV PPIs might not outweigh non–high-dose PPIs.