RT Journal
A1 Bell J, Strandberg TE, Teramura-Gronblad M, Laurila JV, Tilvis RS, Pitkälä KH
T1 USe of proton pump inhibitors and mortality among institutionalized older people
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD September 27
VO 170
IS 17
SP 1604
OP 1605
DO 10.1001/archinternmed.2010.304
UL http://dx.doi.org/10.1001/archinternmed.2010.304
AB 
Evidence is accumulating in relation to adverse events associated with proton pump inhibitors (PPIs). Reports in the Archives have demonstrated an association with fractures,1Clostridium difficile infections,2 and community-acquired pneumonia.3 Proton pump inhibitors may also attenuate the antiplatelet benefits of clopidogrel.4 Because frail older people often use PPIs and may be especially vulnerable, we investigated the association between PPIs and all-cause mortality in 2 cohorts of institutionalized people.