RT Journal A1 Esposito K, Giugliano D T1 Lifestyle and adiponectin level: Four-year follow-up of controlled trials JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD July 26 VO 170 IS 14 SP 1270 OP 1271 DO 10.1001/archinternmed.2010.246 UL http://dx.doi.org/10.1001/archinternmed.2010.246 AB The adiponectin adipocyte-secreted adipokine has both insulin-enhancer and anti-inflammatory properties1 and is the most consistent biochemical predictor of type 2 diabetes mellitus. Higher adiponectin levels are consistently associated with a lower risk of type 2 diabetes in 13 prospective studies of diverse populations with a total of 14 598 participants and 2623 incident cases of type 2 diabetes, with a relative risk of 0.72 (95% confidence interval, 0.67-0.78) per 1-log μg/mL increment in adiponectin levels.2 Identification of lifestyle changes able to increase adiponectin circulating levels may help refine the strategy against the current diabetes epidemics.