RT Journal A1 Largent EA, Miller FG, Pearson SD T1 THe pharmacist's role in off-label prescribing—reply JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD April 12 VO 170 IS 7 SP 658 OP 658 DO 10.1001/archinternmed.2010.71 UL http://dx.doi.org/10.1001/archinternmed.2010.71 AB In his letter, Dr Rupp raised a salient point regarding the difficulties posed to pharmacists by off-label prescribing and the relevant regulations. Clearly, off-label prescribing is an issue confronted not merely by patients and physicians. Fortunately, these additional stakeholders might also make unique contributions in addressing our concerns about evidence-based medicine, evidence development, patient notification, and health care costs. Dr Rupp's discussion of e-prescribing provides one example of this. We caution that any workable system should not interfere with patients receiving medications promptly or place an undue administrative burden on clinicians and pharmacists.