RT Journal A1 Rupp MT T1 THe pharmacist's role in off-label prescribing JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD April 12 VO 170 IS 7 SP 658 OP 658 DO 10.1001/archinternmed.2010.70 UL http://dx.doi.org/10.1001/archinternmed.2010.70 AB It is important to consider that the drug utilization review (DUR) provisions of the Omnibus Budget Reconciliation Act of 1990 (OBRA ’90) required pharmacists to evaluate physicians' prescription orders prior to dispensing to ensure that prescribed medications are “appropriate, medically necessary, and are not likely to result in adverse events.”2 Following the implementation of this law in 1993, these DUR provisions were written into virtually every state pharmacy practice act, thereby making them a legal responsibility of pharmacists. This responsibility specifically includes evaluating the appropriateness of prescribed medication for the patient.