RT Journal
A1 Odeh M, Schiff E, Oliven A
T1 HYponatremia during therapy with amiodarone
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD November 22
VO 159
IS 21
SP 2599
OP 2600
DO 10.1001/archinte.159.21.2599
UL http://dx.doi.org/10.1001/archinte.159.21.2599
AB We describe an elderly woman who presented with significant hyponatremia caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) during therapy with amiodarone. The hyponatremia resolved after discontinuation of the drug and did not recur during a follow-up period of 6 months. Such an association has previously been reported only once in the medical literature. Since severe hyponatremia can produce significant neurologic damage and is associated with a high mortality rate, clinicians should be aware that this complication may occur during amiodarone therapy.