RT Journal
A1 Jochimsen EM, Luo C, Beltrami JF, Respess RA, Schable CA, Cardo DM
T1 INvestigations of possible failures of postexposure prophylaxis following occupational exposures to human immunodeficiency virus
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD October 1
VO 159
IS 19
SP 2361
OP 2363
DO 10.1001/archinte.159.19.2361
UL http://dx.doi.org/10.1001/archinte.159.19.2361
AB 
Although evidence suggests that PEP may be effective,3 failures of PEP with zidovudine have been reported.4- 5 It is likely that failures of PEP with combination therapy also will occur, and one possible case has recently been described.6 Since little is known about the effectiveness of PEP for occupational HIV exposures, investigation of cases of possible PEP failure can provide important information about factors that may influence PEP efficacy and occupational HIV transmission. Reports of PEP failure may help direct future epidemiologic or laboratory studies in this area and potentially could influence recommendations for management of occupational HIV exposures.