RT Journal
A1 Tetiker T, Sert M, Koçak M
T1 EFficacy of indapamide in central diabetes insipidus
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD September 27
VO 159
IS 17
SP 2085
OP 2087
DO 10.1001/archinte.159.17.2085
UL http://dx.doi.org/10.1001/archinte.159.17.2085
AB Background 
    Central diabetes insipidus (CDI) results from deficient vasopressin (antidiuretic hormone) secretion and causes polydipsia and polyuria. Desmopressin, a synthetic analog of vasopressin, is the drug of choice in the treatment of CDI, but in mild cases, there are alternative drugs that can be used, including chlorpropamide, carbamazepine, and thiazides.Methods 
    In this study, we investigated the efficacy of treatment with indapamide, which is an antihypertensive diuretic oral agent, in 20 consecutive patients with CDI. The diagnosis of CDI was established by water-deprivation and vasopressin tests. Before the study, serum and urinary osmolality, daily urinary volume, and serum electrolyte levels were measured in all 20 patients. Indapamide (2.5 mg/d) was administered for 10 days, and then the investigations were performed again; for purposes of comparison, 250 mg/d of chlorpropamide was also administered to 11 of the 20 patients who had been given indapamide.Results 
    Indapamide revealed a 40.56%±9.70% (mean±SD) (range, 19.6%-55.0%) reduction in 24-hour urinary volume and an increase in urinary osmolality, as well as a decrease in serum osmolality, and was as effective as chlorpropamide (P<.05) in the treatment of CDI.Conclusion 
    Because of its low cost and lack of significant adverse effects, indapamide may be a suitable, easy-to-use alternative oral agent for some patients with CDI.