RT Journal
A1 Older J, Older P, Colker J, Brown R
T1 SEcretory villous adenomas that cause depletion syndrome
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1999
FD April 26
VO 159
IS 8
SP 879
OP 880
DO 10.1001/archinte.159.8.879
UL http://dx.doi.org/10.1001/archinte.159.8.879
AB Secretory villous adenomas of the colon have been known to cause a depleting syndrome characterized by dehydration, prerenal azotemia, hyponatremia, hypokalemia, metabolic acidosis, obtundation, and, in severe cases, death. We describe 1 case of classic depleting syndrome and review the literature on possible mechanisms. Both cyclic adenosine monophosphate and prostaglandin E2 have been implicated as possible secretagogue compounds in the pathogenesis of this syndrome unique to the secretory variant form of villous adenomas. Indomethacin as a prostaglandin inhibitor has been used with apparent benefit in controlling the volume of rectal effluent in patients with secretory villous adenomas.