RT Journal
A1 Asamura T, Ohrui T, Une K, Furukawa K, Arai H
T1 CEntrally active aceis and cognitive decline
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD January 11
VO 170
IS 1
SP 107
OP 108
DO 10.1001/archinternmed.2009.463
UL http://dx.doi.org/10.1001/archinternmed.2009.463
AB 
We read with interest the article by Sink and colleagues1 describing an association between the use of centrally active ACEIs that can cross the BBB and a reduction in cognitive decline in a large, well-characterized cohort of treated older adults with hypertension. Using computerized information on patients in our university hospital, we also found that the long-term use of centrally active ACEIs (captopril or perindopril) is associated with a lower risk of incident dementia compared with other antihypertension drugs in elderly hypertensive patients.2 Furthermore, we found that the centrally active ACEIs significantly reduce the rate of cognitive decline in hypertensive patients with mild to moderate AD compared with other antihypertensive drugs, although all participants had a stable and comparable blood pressure.3