RT Journal
A1 Björn P, Anders H
T1 ATovaquone-proguanil use in early pregnancy and the risk of birth defects
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD February 14
VO 171
IS 3
SP 259
OP 260
DO 10.1001/archinternmed.2010.521
UL http://dx.doi.org/10.1001/archinternmed.2010.521
AB 
Malaria infection in pregnancy is associated with increased risk of complications for the mother and fetus,1 particularly in individuals not previously exposed to malaria, eg, travelers. Pregnant women are advised to avoid travel to countries where there is elevated risk of contracting malaria.2- 3 For pregnant individuals who still choose to or must travel to malaria-endemic areas where there is chloroquine resistance, currently none of the available prophylactic drugs are recommended in early pregnancy. This is either owing to adverse fetal effects (doxycycline), paucity of safety data (mefloquine), or absence of such (atovaquone-proguanil).2- 4