RT Journal
A1 Ross C
T1 A possible epigenetic explanation for the relationship between physical activity and exceptional health among older women
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD June 28
VO 170
IS 12
SP 1081
OP 1083
DO 10.1001/archinternmed.2010.192
UL http://dx.doi.org/10.1001/archinternmed.2010.192
AB 
The epigenetic drift theory of aging holds that epimutations that develop over the course of a lifetime, resulting in the deterioration of the epigenome, contribute to the degenerative diseases of aging.2- 3 For example, epigenetic drift leading to hypomethylation of repeat elements and the hypermethylation of the promoters of tumor-suppressor genes is believed to play a role in cancer. Epigenetic mechanisms have also been proposed as a factor in Alzheimer disease, type 2 diabetes mellitus, atherosclerosis, and osteoarthritis.3