RT Journal A1 Redberg RF T1 Computed tomographic scans: Heart and heritable concerns also—reply JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD May 10 VO 170 IS 9 SP 835 OP 836 DO 10.1001/archinternmed.2010.119 UL http://dx.doi.org/10.1001/archinternmed.2010.119 AB Ms O’Connor reminds us of another possible risk of radiation exposure—that of increased heart disease from the effect of ionizing radiation on the gonads in causing heritable mutations. I agree that the best way to optimize the risk to benefit ratio is to be sure that only indicated CT scans are performed using the optimal least-radiation protocol.