RT Journal
A1 O’Connor E
T1 Computed tomographic scans: Heart and heritable concerns also
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2010
FD May 10
VO 170
IS 9
SP 835
OP 836
DO 10.1001/archinternmed.2010.118
UL http://dx.doi.org/10.1001/archinternmed.2010.118
AB 
With respect to radiation-induced coronary artery disease, startling evidence exists for inferring that somatic mutations can initiate and/or accelerate formation of arteriosclerotic plaque and its rupture.2- 3 One proposed mechanism is the production of miniature tumors of mutated, dysfunctional, genomically unstable cells in arterial tissue, resulting in atheromas having fragile fibrous caps that cannot contain thrombogenic lipid pools.3 It is urgent to evaluate such evidence, because beyond doubt, low-dose CT, fluoroscopy, and nuclear medicine increase the burden of mutations accumulated in the coronary arteries.