RT Journal A1 Ding EL, Smit LA, Hu FB T1 The metabolic syndrome as a cluster of risk factors: Is the whole greater than the sum of its parts?: comment on “the metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis” JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD March 8 VO 170 IS 5 SP 484 OP 485 DO 10.1001/archinternmed.2009.552 UL http://dx.doi.org/10.1001/archinternmed.2009.552 AB Two main questions now persist: (1) whether MetS improves prediction and better characterizes people at risk of CVD rather than simply identifies the presence of the individual component risk factors, and (2) whether the syndrome possesses an underlying pathophysiologic characteristic or is merely an aggregated post hoc collection of correlated cardiovascular risk factors.