RT Journal A1 van Troostenburg de Bruyn A, Dormandy J T1 RIsk of thiazolidinedione-associated fracture should be appropriately assessed JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2010 FD January 25 VO 170 IS 2 SP 209 OP 210 DO 10.1001/archinternmed.2009.487 UL http://dx.doi.org/10.1001/archinternmed.2009.487 AB Dormuth et al1 described their study as a prospective cohort study, when in fact it was a retrospective database analysis. It is well recognized that prospective studies offer a higher probability of detecting true associations than retrospective studies because they allow greater control to be exercised over confounding factors and data collection. We do not mean to question the validity of the results of their analysis but to suggest that the data should be interpreted in the context of the retrospective study design used.