RT Journal
A1 Choudhry NK, Fischer MA, Avorn J, et al
T1 THe implications of therapeutic complexity on adherence to cardiovascular medications
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD May 9
VO 171
IS 9
SP 814
OP 822
DO 10.1001/archinternmed.2010.495
UL http://dx.doi.org/10.1001/archinternmed.2010.495
AB 
Effective medications are central to the prevention and management of chronic diseases and their complications. Because many patients have multiple chronic conditions,1 therapeutic regimens often involve multiple medications and frequent daily dosing. Such regimen complexity may undermine effective chronic disease management. For example, patients who are prescribed medications that must be taken multiple times per day are less likely to adhere to their treatments than patients with simpler dosing schedules.2 Interventions that simplify treatment regimens by reducing dosing frequency3 or by switching patients to fixed-dose medication combinations4 result in substantial improvements in appropriate medication use.