RT Journal A1 Moore JC, Ballas ZK T1 REsearch letters JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2009 FD January 26 VO 169 IS 2 SP 199 OP 205 DO 10.1001/archinternmed.2008.580 UL http://dx.doi.org/10.1001/archinternmed.2008.580 AB There is a broad differential to consider when evaluating a patient with angioedema, which can include capillary leak syndrome and lymphedema. Systemic capillary leak syndrome typically presents with hypotension, hemoconcentration, hypoalbuminemia, monoclonal gammopathy, and marked plasma leakage resulting in diffuse edema.1 Prophylactic treatment with terbutaline sulfate and theophylline has been found to be effective for the prevention of systemic capillary leak syndrome exacerbations.2