RT Journal
A1 Fischer MA, Solomon DH, Teich JM, Avorn J
T1 Conversion from intravenous to oral medications: Assessment of a computerized intervention for hospitalized patients
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2003
FD November 24
VO 163
IS 21
SP 2585
OP 2589
DO 10.1001/archinte.163.21.2585
UL http://dx.doi.org/10.1001/archinte.163.21.2585
AB Background 
    Many hospitalized patients continue to receive intravenous medications longer than necessary. Earlier conversion from the intravenous to the oral route could increase patient safety and comfort, reduce costs, and facilitate earlier discharge from the hospital without compromising clinical care. We examined the effect of a computer-based intervention to prompt physicians to switch appropriate patients from intravenous to oral medications.Methods 
    This study was performed at Brigham and Women's Hospital, an academic tertiary care hospital at which all medications are ordered online. We targeted 5 medications with equal oral and intravenous bioavailability: fluconazole, levofloxacin, metronidazole, ranitidine, and amiodarone. We used the hospital's computerized order entry system to prompt physicians to convert appropriate intravenous medications to the oral route. We measured the total use of the targeted medications via each route in the 4 months before and after the implementation of the intervention. We also measured the rate at which physicians responded to the intervention when prompted.Results 
    The average intravenous defined daily dose declined by 11.1% (P = .002) from the preintervention to the postintervention period, while the average oral defined daily dose increased by 3.7% (P = .002). Length of stay, case-mix index, and total drug use at the hospital increased during the study period. The average total monthly use of the intravenous preparation of all of the targeted medications declined in the 4 months after the intervention began, compared with the 4 months before. In 35.6% of 1045 orders for which a prompt was generated, the physician either made a conversion from the intravenous to the oral version or canceled the order altogether.Conclusions 
    Computer-generated reminders can produce a substantial reduction in excessive use of targeted intravenous medications. As online prescribing becomes more common, this approach can be used to reduce excess use of intravenous medications, with potential benefits in patient comfort, safety, and cost.