RT Journal
A1 Akhund L, Quinet RJ, Ishaq S
T1 CElecoxib-related renal papillary necrosis
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2003
FD January 13
VO 163
IS 1
SP 114
OP 115
DO 10.1001/archinte.163.1.114
UL http://dx.doi.org/10.1001/archinte.163.1.114
AB Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2–specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2–specific inhibitors.