RT Journal
A1 Martin SS, Blaha MJ, Jones SR
T1 Nonfasting lipids: There is the population and then there is the patient
JF JAMA Internal Medicine
JO JAMA Internal Medicine
YR 2013
FD May 27
VO 173
IS 10
SP 936
OP 937
DO 10.1001/jamainternmed.2013.383
UL http://dx.doi.org/10.1001/jamainternmed.2013.383
AB
In primary care offices, low-density lipoprotein cholesterol (LDL-C) is the central focus on lipids, as recommended by worldwide dyslipidemia treatment guidelines.2,3 For 4 decades, the medical community has estimated LDL-C level by the Friedewald equation.4,5 The equation performs very well at a population level. However, as Dr Friedewald described,4 simply dividing triglyceride level by 5 does not give a very accurate estimate of very large-density lipoprotein cholesterol (VLDL-C)â€”the importance of inaccuracy depends on what fraction of the equation VLDL-C constitutes in the individual patient.