RT Journal
A1 Takagi H, Umemoto T, ALICE (All-Literature Investigation of Cardiovascular Evidence) Group f
T1 Limit to benefits of large reductions in low-density lipoprotein cholesterol levels: Use of fractional polynomials to assess the effect of low-density lipoprotein cholesterol level reduction in metaregression of large statin randomized trials
JF JAMA Internal Medicine
JO JAMA Internal Medicine
YR 2013
FD June 10
VO 173
IS 11
SP 1028
OP 1029
DO 10.1001/jamainternmed.2013.659
UL http://dx.doi.org/10.1001/jamainternmed.2013.659
AB
Conventional metaregressions such as the one by Delahoy et al,1 however, rely on “linear” modeling, which assumes that the association fits a line (a constantly increasing or decreasing risk as the exposure increases or decreases) and does not allow for alternative associations such as threshold effects. We performed a “flexible” (not “linear”) unrestricted maximum-likelihood metaregression (inverse variance-weighted regression) based on fractional polynomials2 of the reduction in LDL-C level on the logarithmic relative risk (RR) for major vascular events.