RT Journal
A1 Tarapués M, Cereza G, Figueras A
T1 New statins also produce fatigue: Spontaneous reporting as a complementary system to increase safety knowledge
JF JAMA Internal Medicine
JO JAMA Internal Medicine
YR 2013
FD February 11
VO 173
IS 3
SP 247
OP 248
DO 10.1001/jamainternmed.2013.1614
UL http://dx.doi.org/10.1001/jamainternmed.2013.1614
AB 
We have read with interest the Research Letter by Golomb et al1 about the effects of statins on energy and fatigue with exertion. The Research Letter describes the first randomized evidence of these adverse drug reactions (ADRs) for simvastatin and pravastatin, previously reported as anecdotal cases in the literature. The study attracted our attention because it has tied up loose ends after signal detection by pharmacovigilance systems based on spontaneous reporting. Notwithstanding, at the same time it has been a stimulus to look for new data after posing the question “Do the new statins also produce these adverse effects?”