RT Journal
A1 Minichiello T
T1 Moderate renal impairment and risk of bleeding with anticoagulation: Comment on “enoxaparin outcomes in patients with moderate renal impairment”
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD December 10
VO 172
IS 22
SP 1718
OP 1720
DO 10.1001/2013.jamainternmed.456
UL http://dx.doi.org/10.1001/2013.jamainternmed.456
AB 
Dosing of warfarin and unfractionated heparin is complicated, requiring frequent assessment of coagulation variables and dose titration. Low-molecular-weight heparins boast a more predictable dose-response effect and hence freedom from routine laboratory monitoring. Similarly, the new oral anticoagulants are administered at a set dose, with no need for routine laboratory monitoring and dose adjustment. Ideally, the more reliable anticoagulant effect and ease of dosing would lead to fewer bleeding complications related to overanticoagulation with these agents.