RT Journal
A1 Gomes T, Mamdani MM, Holbrook AM, Paterson J, Juurlink DN
T1 PErsistence with therapy among patients treated with warfarin for atrial fibrillation
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD November 26
VO 172
IS 21
SP 1687
OP 1689
DO 10.1001/archinternmed.2012.4485
UL http://dx.doi.org/10.1001/archinternmed.2012.4485
AB 
The major challenges of warfarin therapy relate to poor adherence and persistence, the need for regular monitoring, and the risk of hemorrhage. In clinical trials, persistence with warfarin treatment ranges from 75% to 79% at 1 year,1- 2 but persistence in clinical practice is thought to be poorer. Small observational studies suggest that approximately one-quarter of patients cease warfarin treatment within a year of initiation.3- 4 To our knowledge, there are currently no large studies offering real-world estimates of persistence among warfarin users.