RT Journal
A1 Katz MH
T1 Risks and benefits of medications in real-world practice: Comment on “comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system”
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD November 12
VO 172
IS 20
SP 1590
OP 1590
DO 10.1001/2013.jamainternmed.868
UL http://dx.doi.org/10.1001/2013.jamainternmed.868
AB 
All drugs have adverse effects. The challenge for practicing physicians is to determine which medications have the fewest adverse effects for a given therapeutic benefit. Unfortunately, drugs with similar indications often have not been directly compared with one another because their approvals were based on comparison with placebo or with only one member of the same or a similar class. Moreover, the comparable risks for unusual adverse effects with a group of different medications having similar indications can be even more challenging because most phase 3 efficacy trials are not powered to accurately estimate or even detect the incidence of unusual occurrences.