RT Journal A1 Kwak S, Myung S T1 The big ones that got away: Omega-3 meta-analysis flawed by excluding the biggest fish oil trials—reply JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2012 FD October 8 VO 172 IS 18 SP 1427 OP 1428 DO 10.1001/archinternmed.2012.4300 UL http://dx.doi.org/10.1001/archinternmed.2012.4300 AB Fifth, most trials included in the present meta-analysis had a small sample size of 59 to 500 participants and a short duration of treatment of less than 2 to 3 years. Further larger trials are needed.