RT Journal
A1 Novack V, Cohen DJ, Cutlip DE
T1 Misconstrued intentions: Setting the record straight
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD October 8
VO 172
IS 18
SP 1425
OP 1427
DO 10.1001/archinternmed.2012.3752
UL http://dx.doi.org/10.1001/archinternmed.2012.3752
AB 
In particular, we were disappointed to discover that the objective and major conclusions of our study were misinterpreted within the commentary. As clearly outlined in the article, our aim was to compare the effects of a troponin- or creatine kinase–MB (CKMB)-based definition of periprocedural myocardial infarction (MI) on event frequency and the association of these events with 1-year mortality. Our results indicated a significant difference in sensitivity such that the frequency of troponin MI (troponin values >3 times the upper limit of normal [ULN]) was more than 3-fold higher than CKMB MI (CKMB values >3 times the ULN). Moreover, although elevations of both troponin and CKMB levels were prognostically important, a comparable association between biomarker elevation and 1-year mortality was observed at much higher relative elevations of troponin than CKMB. Our article did not suggest a preference for CKMB or state that CKMB assays were more reliable based on longer-term use.