RT Journal A1 Cantrell L, Suchard JR, Wu A, Gerona RR T1 STability of active ingredients in long-expired prescription medications JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2012 FD November 26 VO 172 IS 21 SP 1685 OP 1687 DO 10.1001/archinternmed.2012.4501 UL http://dx.doi.org/10.1001/archinternmed.2012.4501 AB Debate exists regarding the relative potency of medications beyond their labeled expiration dates. Expired medications have not necessarily lost potency, since the expiration date is only an assurance that the labeled potency will last at least until that time.1 Clinical situations may arise in which expired drugs might be considered owing to lack of viable alternatives2 or financial concerns.3 Ongoing studies show that many medications retain their potency years after their initially labeled expiration dates.4 We sought to characterize the potency of some prescription medications that had expired decades ago.