RT Journal
A1 van der Ploeg HP, Banks E, Bauman A
T1 IS sitting harmful to health? it is too early to say—reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD September 10
VO 172
IS 16
SP 1272
OP 1273
DO 10.1001/archinternmed.2012.2953
UL http://dx.doi.org/10.1001/archinternmed.2012.2953
AB 
The responses to our recent article on sitting time and mortality1 highlight the interest in, and potential importance of, sedentary behaviors and health. Our original article found that prolonged sitting was associated with increased all-cause mortality risk, independent of physical activity.1 A study limitation was the relatively short follow-up time (mean, 2.8 years), potentially leading to confounding by occult disease. However, findings persisted after adjustments (for demographic variables, physical activity, body mass index, smoking, self-rated health, and disability), chronic disease stratification, and sensitivity analyses excluding deaths in the first year. Nevertheless, neither reverse causality due to occult disease nor residual confounding could be completely excluded.1