RT Journal A1 Andrade C, Fernandes P T1 IS sitting harmful to health? it is too early to say JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2012 FD September 10 VO 172 IS 16 SP 1272 OP 1273 DO 10.1001/archinternmed.2012.2539 UL http://dx.doi.org/10.1001/archinternmed.2012.2539 AB Van der Ploeg et al1 analyzed prospectively collected data from a large population-based cohort and found that, regardless of age, sex, body mass index, self-rated health, level of physical activity, baseline cardiovascular disease and diabetes, and other confounders, longer hours of sitting were dose-dependently associated with greater risk of all-cause mortality across an average of 2.8 years of follow-up. They described mechanisms and cited previous literature to support a hypothesis that excessive sitting, independent of physical activity, is harmful to health.