RT Journal
A1 Alam A, Gomes T, Bell CM
T1 Long-term analgesic use: Sometimes less is not more—reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD August 13
VO 172
IS 15
SP 1189
OP 1190
DO 10.1001/archinternmed.2012.2897
UL http://dx.doi.org/10.1001/archinternmed.2012.2897
AB 
Our cohort was specifically designed to minimize any confounding by excluding patients with prior pain medication use. Unfortunately, this was not incorporated in the cohort study2 cited by Drs Krishnamoorthy and Bhalla. Hence, we believe the pain requirements of our patient cohort can more likely be attributed to the surgery and postoperative prescriptions. Furthermore, we believe the prevalence of pain in the cited single-center comparator cohorts are likely far lower owing to low responder biases.