RT Journal
A1 Katz MH
T1 For human immunodeficiency virus disease, more treatment seems to be better: Comment on “immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to hiv seroconversion”
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD September 10
VO 172
IS 16
SP 1256
OP 1256
DO 10.1001/archinternmed.2012.2776
UL http://dx.doi.org/10.1001/archinternmed.2012.2776
AB 
Lodi and colleagues address whether short-term combination antiretroviral therapy at the time of HIV seroconversion would enable some patients to control the virus without treatment. If early treatment enabled control in some patients, it could decrease exposure to HIV medications and, thus, the adverse effects. Unfortunately, this cohort study demonstrates that few individuals are able to control the infection without treatment. Because HIV treatment has become more effective, with fewer adverse effects, and we have gained a better appreciation of the subtle harms that HIV causes, even when the patient seems healthy, the balance is increasingly moving toward initiation of treatment at seroconversion and maintenance of treatment thereafter. In the case of antiretroviral treatment for HIV, more treatment seems to be better.