RT Journal A1 Marcus DM, Grollman AP T1 THe consequences of ineffective regulation of dietary supplements JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2012 FD July 9 VO 172 IS 13 SP 1035 OP 1036 DO 10.1001/archinternmed.2012.2687 UL http://dx.doi.org/10.1001/archinternmed.2012.2687 AB Under DSHEA, manufacturers of dietary supplements are not required to provide premarketing evidence of safety or efficacy or, prior to 2007, to report adverse events. After 1994, sales of supplements rose rapidly, and in 2007, consumers spent $14.8 billion out of pocket for nonvitamin, nonmineral products such as herbals.2 Increased consumption of supplements was accompanied by reports of serious adverse events and adulteration of dietary supplements by prescription drugs and heavy metals.3