RT Journal A1 You Y T1 RIsk factors for young-onset advanced colorectal cancer—reply JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2012 FD June 25 VO 172 IS 12 SP 971 OP 972 DO 10.1001/archinternmed.2012.2001 UL http://dx.doi.org/10.1001/archinternmed.2012.2001 AB We agree that the value and the cost-effectiveness of broadening colorectal cancer (CRC) screening practice to all young adults remain to be determined. Our current analysis,1 the largest cohort study to date that examined the problem of CRC incidence among adults younger than 50 years, highlights the steadily increasing incidence of CRC in this patient population and adds to recent findings from the Surveillance, Epidemiology and End Results (SEER) program.2- 4 Taken together, we hope that this alarming epidemiologic trend would no longer be dismissed as unimportant. It is our opinion that this observed incidence trend merits greater vigilance in evaluating symptoms consistent with CRC in the young adult population, when health care professionals encounter such a clinical situation.