RT Journal
A1 Suzuki M, Muro S, Ando Y, et al
T1 A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (copd): The copd-acupuncture trial (cat)
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD June 11
VO 172
IS 11
SP 878
OP 886
DO 10.1001/archinternmed.2012.1233
UL http://dx.doi.org/10.1001/archinternmed.2012.1233
AB Background 
                  Dyspnea on exertion (DOE) is a major symptom of chronic obstructive pulmonary disease (COPD) and is difficult to control. This study was performed to determine whether acupuncture is superior to placebo needling in improving DOE in patients with COPD who are receiving standard medication.Methods 
                  Sixty-eight of 111 patients from the Kansai region of Japan who were diagnosed as having COPD and were receiving standard medication participated in a randomized, parallel-group, placebo-controlled trial (July 1, 2006, through March 31, 2009) in which the patients, evaluators, and statistician were unaware of the random allocation. Participants were randomly assigned to traditional acupuncture (real acupuncture group, n = 34) or placebo needling (placebo acupuncture group, n = 34). Both groups received real or placebo needling at the same acupoints once a week for 12 weeks. The primary end point was the modified Borg scale score evaluated immediately after the 6-minute walk test. Measurements were obtained at baseline and after 12 weeks of treatment.Result 
                  After 12 weeks, the Borg scale score after the 6-minute walk test was significantly better in the real acupuncture group compared with the placebo acupuncture group (mean [SD] difference from baseline by analysis of covariance, −3.6 [1.9] vs 0.4 [1.2]; mean difference between groups by analysis of covariance, −3.58; 95% CI, −4.27 to −2.90). Patients with COPD who received real acupuncture also experienced improvement in the 6-minute walk distance during exercise, indicating better exercise tolerance and reduced DOE.Conclusion 
                  This study clearly demonstrates that acupuncture is a useful adjunctive therapy in reducing DOE in patients with COPD.Trial Registration 
                  umin.ac.jp/ctr Identifier: UMIN000001277