RT Journal
A1 Ioannidis JA
T1 INvited commentary—genetic prediction for common diseases
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD May 14
VO 172
IS 9
SP 744
OP 746
DO 10.1001/archinternmed.2012.931
UL http://dx.doi.org/10.1001/archinternmed.2012.931
AB 
A major promise of human genetics has been the use of genetic information to predict the risk of common diseases in order to prevent and treat these conditions more effectively. Most common diseases have a complex etiology, and genes are expected to explain much of their risk. However, even though PubMed already retrieves more than 2 million articles with “gene OR genetic” (n = 2 015 109 as of February 10, 2011) and half (n = 1 040 434) are tagged as “Human,” there are formidable difficulties in materializing this promise.1