RT Journal
A1 Gupta BP, Murad M, Kopechy SL
T1 Lifestyle for erectile dysfunction: A good choice—reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD February 13
VO 172
IS 3
SP 296
OP 297
DO 10.1001/archinternmed.2011.805
UL http://dx.doi.org/10.1001/archinternmed.2011.805
AB 
If we consider an IIEF-5 score of 22 or higher to be consistent with the achievement of normal sexual function after lifestyle intervention and cardiovascular risk factors reduction, we would have data available from 3 studies.1- 3 A fixed-effect meta-analysis of these 3 studies revealed that lifestyle interventions reduce the odds of erectile dysfunction (ED) (odds ratio, 0.48; 95% CI, 0.26-0.89). This effect lost statistical significance under a random effects model but remained as a strong trend. The heterogeneity of this meta-analysis was likely due to differences in study populations. In contrast to the relatively younger and nondiabetic populations in the studies by Esposito et al,1- 2 the study population of Wing et al3 consisted of diabetic men with average age of 60 years, explaining the irreversibility of ED.