RT Journal
A1 Cornet AD, Kooter AJ, Peters ML, Smulders YM
T1 Supplemental oxygen therapy in medical emergencies: More harm than benefit?
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD February 13
VO 172
IS 3
SP 289
OP 290
DO 10.1001/archinternmed.2011.624
UL http://dx.doi.org/10.1001/archinternmed.2011.624
AB 
Over the decades, however, potential detrimental effects of supplemental oxygen appear to have been ignored. Many clinicians are unaware of the variety of preclinical studies that have been executed, showing that hyperoxia causes both coronary and systemic vasoconstriction, resulting in deterioration of several important (hemodynamic) parameters (Table). The prime candidate mechanism for these unintended effects is believed to be the formation of reactive oxygen species. In this Research Letter, we draw attention to the collective clinical evidence, which argues against the routine use of high-dose oxygen. Awaiting more thorough studies, we strongly recommend a policy of careful, titrated oxygen supplementation.