RT Journal
A1 You Y, Xing Y, Feig BW, Chang GJ, Cormier JN
T1 Young-onset colorectal cancer: Is it time to pay attention?
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD February 13
VO 172
IS 3
SP 287
OP 289
DO 10.1001/archinternmed.2011.602
UL http://dx.doi.org/10.1001/archinternmed.2011.602
AB 
The 2010 Annual Report to the Nation on Cancer celebrated a steady decline in the incidence of colorectal cancer (CRC).1 This progress has been largely attributed to CRC screening, recommended for adults 50 years or older since 1996.2 In sharp contrast to overall trends, the incidence of CRC appears to be increasing among adults younger than 50 years,1,3 a group for whom average-risk screening is not routine. Particularly concerning is a trend toward advanced-stage CRCs,1,3 suggesting a potential role for increased clinical vigilance and more prompt evaluation of symptomatic patients. To raise clinical awareness and facilitate recognition, we undertook a cohort study to (1) examine incidence trends; (2) define the distinct clinicopathologic manifestations of young-onset CRC; and (3) identify risk factors for advanced-stage disease.