RT Journal
A1 Simonelli S, Gianazza E, Mombelli G, et al
T1 Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cHolesterol acyltransferase in non-hodgkin lymphoma
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2012
FD January 23
VO 172
IS 2
SP 179
OP 181
DO 10.1001/archinternmed.2011.661
UL http://dx.doi.org/10.1001/archinternmed.2011.661
AB An antibody against the lecithin:cholesterol acyltransferase (LCAT) enzyme, which negates cholesterol esterification in plasma, causing severe high-density lipoprotein deficiency (HD), was identified in a woman with a large-cell non-Hodgkin lymphoma. Successful treatment of the lymphoma resulted in clearance of the antibody and complete correction of the defective cholesterol esterification and HD. To our knowledge, an acquired LCAT deficiency leading to severe HD has not been reported previously in association with a malignant disease, and this patient represents the first such documented case.