RT Journal
A1 Moser M, Feig PU
T1 FIfty years of thiazide diuretic therapy for hypertension
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2009
FD November 9
VO 169
IS 20
SP 1851
OP 1856
DO 10.1001/archinternmed.2009.342
UL http://dx.doi.org/10.1001/archinternmed.2009.342
AB Background 
    The use of thiazide diuretics has decreased over the past 30 years despite data from many well-controlled clinical trials demonstrating that the use of these agents as monotherapy or in combination with other antihypertensive agents will reduce blood pressure and decrease cardiovascular as well as cerebrovascular events.Methods 
    We reviewed clinical and experimental data on thiazide diuretics since their introduction in the late 1950s.Results 
    The results of thiazide-based therapy in young and old are consistently positive despite concerns about some metabolic changes, eg, insulin resistance or hypokalemia, that may occur.Conclusion 
    We conclude that these agents are safe, effective, and well tolerated and should continue to be used either as monotherapy or with other medications in the management of hypertension.