RT Journal A1 Goldstein MR, Mascitelli L, Pezzetta F T1 IS red blood cell distribution width a marker of overall membrane integrity? JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2009 FD September 12 VO 169 IS 16 SP 1539 OP 1540 DO 10.1001/archinternmed.2009.275 UL http://dx.doi.org/10.1001/archinternmed.2009.275 AB Cholesterol, a major and essential structural component of all cell membranes, modulates the functions of membrane proteins and participates in membrane trafficking and signaling processes.2 As a result, alterations in membrane cholesterol content might adversely affect the functions of many organ systems. Interestingly, the quintile of subjects exhibiting the highest baseline RDW and subsequent highest mortality had the lowest baseline prevalence of hypercholesterolemia.1