RT Journal
A1 Barletta JF, El-Ibiary SY
T1 ACid suppressive therapy in noncritically ill patients
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD November 14
VO 171
IS 20
SP 1862
OP 1864
DO 10.1001/archinternmed.2011.513
UL http://dx.doi.org/10.1001/archinternmed.2011.513
AB 
We read with great interest the article by Herzig et al1 describing acid-suppressive therapy and the risk for nosocomial gastrointestinal tract (GI) bleeding. The authors have reported the incidence of clinically significant bleeding (which we believe is the most relevant end point) to be extremely low (0.22%), resulting in a number needed to treat to prevent 1 episode of bleeding of 834. This study validates previous statements that acid-suppressive therapy should not routinely be administered to noncritically ill patients or patients who lack major risk factors for stress-related clinically significant bleeding.2