RT Journal
A1 Gosmanov AR, Gosmanova EO
T1 Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: An analysis of the dcct/edic cohort
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD September 26
VO 171
IS 17
SP 1596
OP 1597
DO 10.1001/archinternmed.2011.413
UL http://dx.doi.org/10.1001/archinternmed.2011.413
AB 
In the March 14, 2011, issue of the Archives, de Boer et al1 characterize long-term renal outcomes in patients with type 1 diabetes mellitus (T1DM) and microalbuminuria from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. The data indicate that, within 10 years after commencement of microalbuminuria in patients with T1DM, 40% of patients will regress to normoalbuminuria and 47% of patients will progress to severe nephropathy. After rigorous statistical analysis, the authors identified several clinical factors that were associated with favorable microalbuminuria outcomes such as lower blood pressure, lower glycated hemoglobin level, absence of retinopathy, and favorable lipid profile. We would like to note that the authors have not discussed several facts learned from genetic analyses of T1DM studies including the DCCT study that could be worth mentioning.