RT Journal
A1 Gray L, Lee I, Sesso HD, Batty G
T1 Body weight in early and mid-adulthood in relation to subsequent coronary heart disease mortality: 80-year follow-up in the harvard alumni study
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD October 24
VO 171
IS 19
SP 1768
OP 1770
DO 10.1001/archinternmed.2011.486
UL http://dx.doi.org/10.1001/archinternmed.2011.486
AB 
In the very few studies conducted,1- 4 obesity in young adults is generally associated with an increased risk of future coronary heart disease (CHD). However, data interpretation is complicated by methodological limitations, which include small study size; a paucity of studies examining the impact of confounding factors; and unexplored mechanisms, including the essentially unknown contributions of early vs later body weight on CHD risk,5- 6 which has implications for weight control interventions. In the largest and best characterized study to date, to our knowledge, we directly address these shortcoming.